?????????????

?????????????
?????????????????? ????
???????	/?d?ks??sa?kli?n/; DOKS-iss-EYE-kleen
????????? ???	Doryx, Vibramycin, others
????????/; ??????.??	????????
????????????	a682063
???????? ??????	US ????????: Doxycycline; US ?????: Doxycycline;
??????????? ??????	???????: ??; ;
?????????; ?????	By mouth, intravenous
????? ???	J01AA02 (???????????) A01AB22;
???? ??????
???? ??????	AU: ??? (???? ????????) ; UK: ????? (???? ????????) ; US: ???? ? ;
???????????????? ??????
????????????	~100%
??????? ?????	80–90%
?????	Negligible
????? ????-????	10–22 hours
????	Mainly faeces, 40% urine
??????????
	????????? ??? (4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide;
????? ?????	564-25-0 ;
?????? ??????	Doxycycline;
???????????	DB00254 ;
???????????	10482106 ;
????????	334895S862;
???????	D00307 ;
??????????	??????????:60648 ;
????????????	????????????1433 ;
??????? ?????????? (?????)	DTXSID0037653 ;
??????? ?????????	100.008.429
????????? ? ??? ????
?????	C22H24N2O8
????? ??	???.?? g·mol??
?????? ???? (???????)	??????????????? ?????;
	??????????? CN(C)[C@@H]3C(\O)=C(\C(N)=O)C(=O)[C@@]4(O)C(/O)=C2/C(=O)c1c(cccc1O)[C@H](C)[C@H]2[C@H](O)[C@@H]34;
	??????????? InChI=1S/C22H24N2O8.H2O/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);1H2/t7-,10+,14+,15-,17-,22-;/m0./s1 ; Key:XQTWDDCIUJNLTR-CVHRZJFOSA-N ;

百度不过仔细看看，袁姗姗的减肥食谱跟传说中的那些相比还算不上丧心病狂。

????????????? ?? ???? ????-?????????? ??????????????-??????? ????????????????, ?? ???????????? ??? ????????? ???? ?????? ?????? ????? ????????? ????????? ??????? ???? ^[?] ??? ???????????????? ??????????, ????, ?????????????? ???????, ???? ???, ?????, ?????? ??? ????????? ????????? ???? ??????? ???? ??? ??????? ?? ????????? ??????????? ???????? ????? ??????? ???? ????????????? ??? ????? ?? ?????? ????????? ??????? ?????? ???? ?????

?????? ???????????????????????? ????? ?????? ?????????, ??? ??? ???, ??? ????? ??? ???? ????? ?????? ?????? ???????????? ??????? ???? ??????? ?????? ??? ??? ????????????? ?? ?????????????? ??????? ???? ????-?????????? ????????????????? ?????????????? ??????? ???????? ???????? ???, ??? ??????? ??????? ???? ????? ?????????????? ??? ??? ?? ???? ????? ^[?] ??? ???? ????????? ????????, ?????????????? ?????? ??? ????????????? ????? ???? ^[?] ^[?]

????????????? ???? ???? ??????? ??? ??????? ??? ???? ???? ????????????? ??????? ??? ???????? ^[?] ^[?] ??? ????? ????????? ??????? ??????????? ?????? ???????? ??????? ^[?] ????????????? ??????? ???? ?????? ?????? ????? ^[?] ???? ????, ??? ??????? ????????????? ???? ???????? ????????? ???? ???, ??? ? ?????????? ???? ????????????? ???? ^[?] ^[??]

?????????

↑ ^? ^? "Doxycycline calcium"? The American Society of Health-System Pharmacists? ?? ?????????? ???? ?????? ??? ???? ??????????? ???????? ????? ?? ????? ?????{{????? ???????}}: ??????? ???? ????????????: ????? ???????????????? ?????? (?????)
↑ Nelson ML, Levy SB (???????? ????)? "The history of the tetracyclines": ??–??? ?????:10.1111/j.1749-6632.2011.06354.x? ???????? 22191524? {{???????? ???????}}: ??????? journal ?? ???? |journal= ???????? (???????)??????? ???? ????????????: ????? ???????????????? ?????? (?????)
↑ McFadden GI (????? ????)? "Apicoplast": R???-?? ?????:10.1016/j.cub.2014.01.024? ???????? 24698369? {{???????? ???????}}: ????? ??????????? |???????-?????= ??????? ??? ?????? (???????); ??????? journal ?? ???? |journal= ???????? (???????)??????? ???? ????????????: ????? ???????????????? ?????? (?????)
↑ Schlagenhauf-Lawlor, Patricia (????)? Travelers' Malaria? PMPH-USA? ??. ???? ???????? ??????????????{{?? ???????}}: ??????? ???? ????????????: ????? ???????????????? ?????? (?????)
↑ Fischer, Janos; Ganellin, C. Robin (????)? Analogue-based Drug Discovery (?????? ??????)? John Wiley & Sons? ??. ???? ???????? ??????????????{{?? ???????}}: ??????? ???? ????????????: ????? ???????????????? ?????? (?????)
↑ Corey, E.J. (????)? Drug discovery practices, processes, and perspectives? John Wiley & Sons? ??. ???? ???????? ??????????????{{?? ???????}}: ??????? ???? ????????????: ????? ???????????????? ?????? (?????)
↑ World Health Organization (????)? World Health Organization model list of essential medicines: 21st list 2019? World Health Organization? WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO?{{?? ???????}}: ??????? ???? ????????????: ????? ???????????????? ?????? (?????)
↑ Hamilton, Richard J. (????)? Tarascon pharmacopoeia (12th ???????)? Jones & Bartlett Learning? ??. ??? ???????? ??????????????{{?? ???????}}: ??????? ???? ????????????: ????? ???????????????? ?????? (?????)
↑ "The Top 300 of 2019"? ClinCalc? ???????? ????? ?? ??????? ?????{{????? ???????}}: ??????? ???? ????????????: ????? ???????????????? ?????? (?????)
↑ "Doxycycline - Drug Usage Statistics"? ClinCalc? ???????? ????? ?? ??????? ?????{{????? ???????}}: ??????? ???? ????????????: ????? ???????????????? ?????? (?????)

?????????

"Doxycycline"? Drug Information Portal? U.S. National Library of Medicine?

[AHFS2015-1] ? ^? "Doxycycline calcium"? The American Society of Health-System Pharmacists? ?? ?????????? ???? ?????? ??? ???? ??????????? ???????? ????? ?? ????? ?????{{????? ???????}}: ??????? ???? ????????????: ????? ???????????????? ?????? (?????)

[Tetrahist-2] Nelson ML, Levy SB (???????? ????)? "The history of the tetracyclines": ??–??? ?????:10.1111/j.1749-6632.2011.06354.x? ???????? 22191524? {{???????? ???????}}: ??????? journal ?? ???? |journal= ???????? (???????)??????? ???? ????????????: ????? ???????????????? ?????? (?????)

[3] McFadden GI (????? ????)? "Apicoplast": R???-?? ?????:10.1016/j.cub.2014.01.024? ???????? 24698369? {{???????? ???????}}: ????? ??????????? |???????-?????= ??????? ??? ?????? (???????); ??????? journal ?? ???? |journal= ???????? (???????)??????? ???? ????????????: ????? ???????????????? ?????? (?????)

[4] Schlagenhauf-Lawlor, Patricia (????)? Travelers' Malaria? PMPH-USA? ??. ???? ???????? ??????????????{{?? ???????}}: ??????? ???? ????????????: ????? ???????????????? ?????? (?????)

[5] Fischer, Janos; Ganellin, C. Robin (????)? Analogue-based Drug Discovery (?????? ??????)? John Wiley & Sons? ??. ???? ???????? ??????????????{{?? ???????}}: ??????? ???? ????????????: ????? ???????????????? ?????? (?????)

[6] Corey, E.J. (????)? Drug discovery practices, processes, and perspectives? John Wiley & Sons? ??. ???? ???????? ??????????????{{?? ???????}}: ??????? ???? ????????????: ????? ???????????????? ?????? (?????)

[WHO21st-7] World Health Organization (????)? World Health Organization model list of essential medicines: 21st list 2019? World Health Organization? WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO?{{?? ???????}}: ??????? ???? ????????????: ????? ???????????????? ?????? (?????)

[Rich2011-8] Hamilton, Richard J. (????)? Tarascon pharmacopoeia (12th ???????)? Jones & Bartlett Learning? ??. ??? ???????? ??????????????{{?? ???????}}: ??????? ???? ????????????: ????? ???????????????? ?????? (?????)

[9] "The Top 300 of 2019"? ClinCalc? ???????? ????? ?? ??????? ?????{{????? ???????}}: ??????? ???? ????????????: ????? ???????????????? ?????? (?????)

[10] "Doxycycline - Drug Usage Statistics"? ClinCalc? ???????? ????? ?? ??????? ?????{{????? ???????}}: ??????? ???? ????????????: ????? ???????????????? ?????? (?????)

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